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Hyperthyroidism

Hyperthyroidism is a disease caused by abnormalities of the thyroid gland, an organ found on either side of the windpipe at the base of the neck. The gland produces thyroid hormone which helps to regulate your cat's metabolism, or rate of bodily activity. When the thyroid gland produces too much hormone, your cat's 'internal motor' effectively goes into overdrive. Untreated this would eventually be fatal but the condition can now be successfully treated.

• What causes the disease?

Hyperthyroidism was first seen in cats as recently as 30 years ago and appears to be caused by a form of benign cancer in the thyroid gland. However, it is still not clear what causes the cancer to develop. The disease is rare in young cats but becomes more common in later life. It is now the most frequent hormonal disease in middle-aged and older cats.

• What are the symptoms?

The first indication that anything is wrong is usually a marked increase in your cats’ appetite.  Even though it is given adequate food, your cat may lose weight and its coat may become thin and unkempt.  Other changes include increased activity and aggression, body tremors, increased drinking and urinating, vomiting and diarrhoea.  In about one case in ten the symptoms are unusual and the opposite of what might be expected, such as depression, loss of appetite and physical weakness.

• How can my vet diagnose hyperthyroidism?

Apart from recognising the above clinical symptoms, there are a number of other steps in making a diagnosis. When your vet examines your ca'ts throat the thyroid gland may feel lumpy or enlarged. Blood tests are taken to rule out other diseases of the liver or kidneys. Directly measuring levels of hormone in the blood usually help to confirm the diagnosis.  Your vet will also want to check your cat's heart - an abnormally fast or irregular heart- beat is often a feature. An early diagnosis is important to prevent and even reverse damage to the heart and kidneys. These are the most common causes of death in this disease.

• What are the pros and cons of the different treatment methods?

1.    Medication
There are drugs available which block the production of hormones by the thyroid gland. The medication is given one to three times a day.

Advantages
• Simple and does not require an anaesthetic.
• Suitable for cats with severe kidney disease which might be made worse by the sudden drop in blood pressure which may occur after the other types of treatment.

Disadvantages

• Does not tackle the underlying problem and so treatment must continue throughout your cats life.
• Difficulties in getting your cat to swallow tablets.
• You must remember to give the tablets every day.
• In some cats there are side effects ranging from tiredness to anaemia.
• In the early stages your cat must be carefully monitored to make sure that the dose is right.

2.     Surgical
The abnormal tissue can be surgically removed.

Advantages
• Treatment should permanently cure the disease so no need for further medication.

Disadvantages
• Not suitable for all cats, such as those with severe kidney disease or the very elderly.
• Your cat may need drug treatment for a few weeks beforehand to show that its kidneys will cope and to stabilise their condition before anaesthesia.
• Needs a general anaesthetic which is always a slight risk but more so in ill animals.

3.    Radiation
An injection of radioactive iodine will destroy the abnormal thyroid tissue while leaving normal cells unaffected.

Advantages
• No anaesthetic required and very few unwanted side effects.
• A single treatment will permanently cure the disease in 9 out of 10 cases and a second treatment will do the trick in      most of the rest.
• Radiation will also work in much rarer cases in which the tumour is malignant or where a portion of thyroid tissue has broken away from the main gland and is normally missed during surgery.

    Disadvantages
• Availability - there are only a few places offering the treatment because of tight regulations covering the use of radioactive substances and there is a long waiting list.
• Your cat will have to stay in complete isolation until the radiation level has died down, usually around a week.

• What is best for my cat?

The decision on which method to choose should be made after careful discussion with your vet. Each has advantages and disadvantages and not all may be suitable for your cat. There are a number of things to consider, your cat's age, the severity of the condition, the presence or absence of other diseases and the risk of complications, etc. Cost may also be a factor as both surgery and radiation treatment can involve a significant expense. However, medication may also be costly in a cat diagnosed with the disease relatively early in its life and treated continuously for several years.


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4105169

fh.vets@xtra.co.nz

218 Forrest Hill Road
Forrest Hill
Auckland 0620
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